ncRNA name | PMP22 siRNA |
ncRNA Category | siRNA |
Disease name | proliferative vitreoretinopathy (PVR) |
Species | Homo sapiens |
Tissues/Cell_line | human RPE cell line ARPE-19 |
Methods | siRNA transfection, Western blot, flow cytometry |
Expression pattern | associated |
Functional description | Integrin-mediated collagen gel contraction by ARPE-19 is an in vitro model for proliferative vitreoretinopathy (PVR). PMP22 differentially regulates collagen gel contraction in the ARPE-19 cell line. The decrease in gel contraction by the ARPE-19/PMP22 cells was partially reversed through either PMP22 siRNA or by blockade of AKT. |
PubMed ID | 21421883 |
Year | 2011 |
Title | Rewiring integrin-mediated signaling and cellular response with the peripheral myelin protein 22 and epithelial membrane protein 2 components of the tetraspan web. |
Drug-related ncRNA | NO |
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